The Efficacy of Nebulized Epinephrine in Children with Acute Asthma: A Randomized Double-blind Trial

Introduction: Countries like Bangladesh have seen an increase in the prevalence of bronchial asthma. The goal study was to compare efficacy nebulized salbutamol and epinephrine treating children with acute Objectives: To assess clinical improvement asthma following nebulization epinephrine. Methodology: This random, double-blind trial conducted paediatric department Mymensingh Medical College Hospital. Children either sex features exacerbation asthma, score >5 11, age range from 6 12 years, ability measure peak expiratory flow rate (PEFR) were enrolled this study. Outcomes observed by measuring PEFR, respiratory rate, pulse SaO2 also determining scores at 15, 35, 55, 90 min after a regular interval 0, 20, 40, 60 min. Differences base line differences between both groups observed. Results: A total 56 patients Among them, 27 group, 29 group. baseline characteristics, there no statistically significant difference (p > 0.05) two groups. Asthma decreased more group time nebulization, but existed for follow-up 55 minutes. minutes treatment On other hand, percent predicted PEFR SpO2 increased groups, except 35 epinephrine-treated had higher incidence side effects as compared difference. Conclusion: Based on study, asthmatic mild moderate exacerbation, effective when given addition oral steroids.